PT644. The Possible Action Mechanisms of Central Analgesic Effect of Protocatechuic Acid

s | 35 Conclusions: Our findings provide valuable information for personalized pain treatment after LAC, in which the C allele of the rs2076222 SNP is associated with lower opioid sensitivity and/ or higher pain sensitivity and requires more opioid analgesic after LAC. PT642 The effects of caffeine on acupuncture analgesia Jeong Won Hwang, Shoji Shinohara, Tadashi Watsuji, Katsuki Watanabe Abstract Objective: In the animal study, analgesic effect of acupuncture is reported that there is another route by an adenosine receptor except for opioid system[1]. This study was investigating the effects of acupuncture analgesia by an adenosine receptor. We stimulated to electro-acupuncture(EA) stimulation administered caffeine as an adenosine receptor blockers[2]. Methods: 20 volunteers(male:15, female:5,mean age:24.2 ± 4.4years) who had chronic lumber pain. Randomly divided into two groups: shame group(n=10), administration of caffeine group(n=10, 100mg·kg). Conditions: EA stimulation-100Hz·optimum intensity stimulation·15min once a week for weeks. Acupoints Shenshu(BL-23)·Dachangshu(BL-25), evaluation-by using the Visual Analog Scale(VAS), highest blood pressure, muscle hardness, numerical value of adrenalin and recurrence time of pain. Results: In VAS, highest blood pressure and muscle hardness showed significant differences (p<0.05). The shame group showed a long lasting effects in recurrence of pain. No significant changes were observed in numerical value of adrenalin. Conclusion: It is suggested that administration of caffeine may be effective for preventing from acupuncture analgesia.Objective: In the animal study, analgesic effect of acupuncture is reported that there is another route by an adenosine receptor except for opioid system[1]. This study was investigating the effects of acupuncture analgesia by an adenosine receptor. We stimulated to electro-acupuncture(EA) stimulation administered caffeine as an adenosine receptor blockers[2]. Methods: 20 volunteers(male:15, female:5,mean age:24.2 ± 4.4years) who had chronic lumber pain. Randomly divided into two groups: shame group(n=10), administration of caffeine group(n=10, 100mg·kg). Conditions: EA stimulation-100Hz·optimum intensity stimulation·15min once a week for weeks. Acupoints Shenshu(BL-23)·Dachangshu(BL-25), evaluation-by using the Visual Analog Scale(VAS), highest blood pressure, muscle hardness, numerical value of adrenalin and recurrence time of pain. Results: In VAS, highest blood pressure and muscle hardness showed significant differences (p<0.05). The shame group showed a long lasting effects in recurrence of pain. No significant changes were observed in numerical value of adrenalin. Conclusion: It is suggested that administration of caffeine may be effective for preventing from acupuncture analgesia.